In the breadth of imaginary beings, the creature stands as one of its main creative pillars: from the speculative territories of science fiction to the inhospitable recesses of terror, moving between the pages, screens and scores of our wide diversity of cultures. Within the relationship that creatures have with science, the models of artistic and cultural representation that have woven a wide range of possibilities where they find their points of intersection are well-known: monstrosities born from test tubes, giant animals and other biological alterities, crosses between organisms and machinery, mutants, zombies, etc. Authors such as Mary Shelley, HG Wells or RL Stevenson cultivated the origins of this nexus from literature. Others, such as David Cronenberg, Mark Schultz, Frank R. Paul, HR Giger or Karla Zimonja, continued from cinema, comics, plastic arts, sculpture or video games, respectively. All of them, among many other creators, give a good account of the relevance that exists between science and creatures; and how their themes, points of connection and approaches run through our cultural kaleidoscope.